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Beijing, Feb 12: Researchers have developed a humanized mouse

cd34 humanized mice

model to study liver cyrhosis development induced by hepatitis B virus infection.

nsg mice

Developing an ideal animal model of hepatitis B virus (HBV)

infection is difficult because the virus has an extremely narrow

humanized nsg mice

host range and almost exclusively infects humans, Xinhua News Agency reported.

Previous studies show that mesenchymalstem cells from human bone marrow (hBMSCs) have the potential to differentiate into

humanized nsg mice

hepatocyte-like cells in vitro and continue to maintain vital hepatocyte function in vivo after being transplanted in host mouse livers.

Hepatocytes make up 70 to 85 percent of the liver mass, the researchers from Xiamen University and Zhejiang University, said.

For the study, the research team transplanted hBMSCs in mice.

The mice show robust differentiation and proliferation of functional human hepatocytes and multiple immune cells, according to the research paper published in the British Journal of Gut.

After HBV infection, the humanized mice developed specific

immune and inflammatory responses and showed progression to chronic hepatitis and liver cyrhosis.

The researchers said the new humanized mouse mode

l recapitulates the liver syrhosis induced by human HBV infection, providing the opportunities for better understanding the immune

pathophysiology of HBV and testing promising antiviral therapies in vivo.

According to the World Health Organization, an estimated 257

million people are living with HBV infection, which can cause chronic infection and put people at high risk of cirrhosis and liver cancer.

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